Obesity is a complex complication characterized by excessive accumulation of fat tissue. Obesity is associated with many health problems, including vascular diseases. The discovery of leptin hormone has led to further research on obesity. The main reason for this progress was that it indicated that the fat tissue of the signals is transmitted to the central nervous system. The Leptin produced by the obesity gene is a protein hormone with a molecular weight of 16 kDa, which is mainly secreted from fat tissue, and has a key role in regulating body weight. It is better to say that leptin acts as a warning mechanism for regulating body fat. This hormone increases energy consumption by increasing the activity of the sympathetic nervous system and lipolysis. Leptin also inhibits appetite by influencing hypothalamic receptors. Therefore, the net effect of leptin is to reduce weight, but deficiency of the hormones or resistance to its effects can both lead to weight gain. Leptin resistance, that is associated with its increase in blood, is much more common in human obesity than the deficiency of this hormone. In recent years, numerous studies have been conducted on the association of leptin with arterial hypertension and heart rate. Leptin independent of CRP, that is an inflammatory marker, is associated with vascular disease, and this finding points to the importance of body fat in cardiovascular problems (Astling, 2011). Leptin receptors are on the endothelium wall and smooth vascular muscle cells. For this reason, leptin imposes intermediate is effective on ability and vascular growth. At the cellular level, leptin stimulates smooth muscle for proliferation. Vascular calcification is accelerated by leptin in empirical models. This hormone increases the oxidative pressure in the vascular wall, which can damage them. Therefore, as a general conclusion, it can be concluded that leptin levels in blood are related to cardiovascular health (Thomas, 2014). The findings also indicated that body weight, BMI, FFM / Kg, FM / Kg before and after treatment were not significantly different. The results of the study indicated that the mean of leptin hormone levels in pre- and post-test patients, as well as in the concentration of hormone insulin no significant difference was found. But the mean glucose concentration before and after treatment was statistically significant (p <0.05). Also, the results indicated that the effect of drug use in pre-test and post-test on the level of cholesterol, triglyceride and LDL cholesterol levels in the patients was significantly different. In this study, the effect of metformin during the treatment period reduced the blood glucose level of individuals, but its effect on weight loss and HbA1c did not significantly increase due to the duration of treatment. Various studies have shown that the effect of metformin has significantly reduced blood lipids, which is consistent with the recent study that indicated that cholesterol and triglyceride and LDL cholesterol decreased after treatment. These findings suggest that the drug has an effect on metabolic pathways in addition to glucose lowering the lipids in these patients. Most studies have shown that a balanced, low-fat diet and physical activity reduce levels of leptin in the blood, even if no significant weight loss occurs. Reduced leptin levels through exercise, changes in energy balance, improved insulin sensitivity and changes in blood lipids are appropriate. The study of changes in leptin with physical activity is one of the issues that is especially important in adolescent and youth obesity. At the same time, there are still no other risk factors for vascular diseases, while many studies point to the onset of dryness and vascular trauma in adolescents.