| From the 
                                  Editor..........................................................................................................................
 In this issue of the journal we have various 
                                  rich topics including an update and the evolution 
                                  of the Zika virüs and an opinion paper 
                                  on mental evolution.  A paper from Turkey investigated the seasonal 
                                  variability of AHI values among patients with 
                                  sleep apnea. A total of 304 patients were studied. 
                                  They reviewed the records of patients, including 
                                  their PSGs, and found that their AHI values 
                                  were comparable across seasons. The average 
                                  AHI value for males was 34.95± 29.95 
                                  and 21.88±2.76 for females; they observed 
                                  no significant statistical difference among 
                                  the four groups (both males and females) in 
                                  terms of AHI. Although patient complaints increased 
                                  due to exacerbation of diseases such as asthma 
                                  and allergic rhinitis in the winter, this study 
                                  did not reflect a significant change in AHI 
                                  values. Therefore, PSG examinations do not need 
                                  to be repeated in different seasons. A second paper from Turkey looked at Red blood 
                                  cell supports in severe clinical conditions 
                                  in sickle cell diseases. Sickle cell diseases 
                                  (SCDs) are accelerated atherosclerotic processes. 
                                  As one of the significant endpoints of the SCDs, 
                                  cases with chronic obstructive pulmonary disease 
                                  (COPD) and without were collected into the two 
                                  groups. The study included 428 patients (221 
                                  males). There were 71 patients (16.5%) with 
                                  COPD. Mean age was significantly higher in the 
                                  COPD group (32.8 versus 29.8 years, P=0.005). 
                                  Male ratio was significantly higher in the COPD 
                                  group, too (78.8% versus 46.2%, P<0.001). 
                                  Beside these, priapism (14.0% versus 3.0%, P<0.001), 
                                  HCV RNA positivity (2.7% versus 0.5%, P<0.05), 
                                  cirrhosis (8.4% versus 3.3%, P<0.05), leg 
                                  ulcers (23.9% versus 12.0%, P<0.01), digital 
                                  clubbing (25.3% versus 6.7%, P<0.001), coronary 
                                  heart disease (23.9% versus 13.7%, P<0.05), 
                                  chronic renal disease (15.4% versus 7.0%, P<0.01), 
                                  stroke (16.9% versus 8.1%, P<0.01), and mean 
                                  transfused RBC units in their lives (63.8 versus 
                                  33.0, P=0.003) were all higher among the COPD 
                                  cases. Probably due to the higher number of 
                                  transfused RBC units, the mean age of mortality 
                                  was also higher in the COPD group, significantly 
                                  (38.3 versus 30.4 years, P=0.04). The authors 
                                  concluded that SCDs are chronic catastrophic 
                                  processes on vascular endothelium terminating 
                                  with accelerated atherosclerosis induced end-organ 
                                  failures in early years of life. RBC supports 
                                  in severe clinical conditions probably prolong 
                                  survival of the patients. In the office surgery section there is a review 
                                  of haemorrhoids surgery in the office, from 
                                  Mr Maurice Brygel, Royal Australian College 
                                  of Surgeons (RACS). This edition of the series 
                                  looks at common and thrombosed haemorrhoids 
                                  and their surgical treatment, including rubber 
                                  band ligation. Education covers physical examination, 
                                  operative procedure, risk management and patient 
                                  care and patient education.
 Chief Editor:A. Abyad
 MD, MPH, AGSF, AFCHSE
 Email: aabyad@cyberia.net.lb
   
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