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January 2021 -
Volume 20, Issue 1


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From the Editor

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Awareness and Knowledge about Childhood Autism among Family Medicine Residents in Al Madinah Region in Saudi Arabia, 2020
[pdf]
[Abstract]

Ahmad Mohammed Masarit,Maher Alhafithi, Haytham Alsanna,
Sokinh Almaghaslah
DOI: 10.5742/MEWFM.2022.95201

Exploring the Treatment Types and Challenges in Patients with Chronic Obstructive Pulmonary Disease: A Qualitative Study
[pdf]
[Abstract]

Mian Ali Kamran Baba, Shaheer Ellahi Khan, Fatima Hasnain, Rabab Sakina, Afsheen Talat, Afifa Binte Irfan
DOI: 10.5742/MEWFM.2022.95202

Prevalence and associated factors of burnout among nurses in a general hospital in Yanbu, Saudi Arabia
[pdf]
[Abstract]

Maher Alhafithi, Sami A Al-Dubai, Saleh S Alalwani,
Ahmad M Masarit
DOI: 10.5742/MEWFM.2022.95204

Prevalence of overt and subclinical hypothyroidism during pregnancy in antenatal care - cross-sectional study, Jeddah, Saudi Arabia
[pdf]
[Abstract]

Lubna M. Zahrani, Mada I. Abdulhaq, Taghreed M. Shams, Fayssal M. Farahat
DOI: 10.5742/MEWFM.2022.95206

Prevalence of iron supplementation among pregnant woman in Taif, Saudi Arabia: a cross sectional study
[pdf]
[Abstract]

Amena Ali, Setah J. Aladwani, Awatef M. Alotibi, Ibtihal M. Althumali, Marwah O. Alafghani, Mona S. Alzahrani
10.5742/MEWFM.2022.95209

Why patients go to private health care facilities? Perspectives from Qassim, Saudi Arabia
[pdf]
[Abstract]

Amel A Sulaiman, Unaib Rabbani,, Sultan Alshaya, Marwan Alyahya, Saleh A Al-Gabbany, Chandra S Kalevaru, Saulat Jahan, Raed A Aljubeilan, Ahmed A AlMeman, Bader A AlAhajji
DOI: 10.5742/MEWFM.2022.95212

Population and Community studies

Documentation of paediatric observations in an urgent care setting; a Quality Improvement Project
[pdf]
[Abstract]

Rahma Yusuf Ali
DOI: 10.5742/MEWFM.2022.95210

Public Awareness, and Perception towards Chronic Kidney Disease and its Risk Factors in Southern Region, Saudi Arabia
[pdf]
[Abstract]

Mona Mohammed Alshahrani, Haifa' Hisham A. Alwabel, Hassan Dhafer Hassan Alabisi, Mohammed Abdullah Alshehri, Abdulaziz Mari Alqahtani, Anas Ali Asiri, Manar saeed Alqahtani
DOI: 10.5742/MEWFM.2022.95211

Quality of life for Cardiovascular Patients in Saudi Arabia
[pdf]
[Abstract]

Mohammed M.Mougrabi, Nouran K.Althumali, Raghad S.AL-juaid, Thekra M.Alsalmi, Ohoud D.Alotaibi, Waad S.Alzahrani, Najla J.Alkhaldi
DOI: 10.5742/MEWFM.2022.95214

Stress and a sedentary lifestyle are associated with irritable bowel syndrome in medical students from Saudi Arabia
[pdf]
[Abstract]

Amna Fadl Bashir Fadl, Asrar Mohammed Al-Towerqi, Arwa Abdullah Alharbi,
Danah kamal kabrah, Amwaj Abdulmohsen Almalki, Bashayer Nawar Algethami, Amal Mohammed Albogami
DOI: 10.5742/MEWFM.2022.95216

Physicians' Perceptions and Attitudes toward Use of Electronic Medical Record Systems in Riyadh
[pdf]
[Abstract]

Yasser H. Al Otaib,vMoteb M. AlSaedi
DOI: 10.5742/MEWFM.2022.95218

Job Related Burnout among Emergency Physicians and Nurses
in Dammam City, Saudi Arabia

[pdf]
[Abstract]

Abdulaziz F. Alshahrani, Abdullah M. Alhotheyfa, Salman Z. Alkhiraisy,
Hassan A. Abugad, Bander F. Alshahrani
DOI: 10.5742/MEWFM.2022.95219

Sleep Patterns and Academic Performance among Medicine and Pharm D students in Almaarefa University 2018-2019
[pdf]
[Abstract]

Mashel A. Alzunidi, Jawaher A. Alowayyid, Rabab A.Benhadi, Habiba H. Farouk, Malak H. Alshammari, Asmaa S.Sultan, Rana A.Almojil, Alanoud A.Alshathri, Noor N.Alsalman, Shahad S. Alshaya, Mona M. Alfadeel
DOI: 10.5742/MEWFM.2022.95223

Reviews

Nutrition and puberty
[pdf]
[Abstract]

Dima Naddeh, Alaa Salah AG AlSharei
DOI: 10.5742/MEWFM.2022.95221

Alzheimer's Dementia - A Narrative Review
[pdf]
[Abstract]

Nasir Alzbeidi, Hem Phaterpekar, Hamed Al-Sinawi
DOI: 10.5742/MEWFM.2022.95221

Clinical Research and Audits

Clinical Audit Report on Adherence to Imaging Guidelines for Patients with Acute Low Back Pain in Airport Health Centre
[pdf]
[Abstract]

Hanan Al-shamery, Wesam Abouamer, Neelufur Sulaiman
DOI: 10.5742/MEWFM.2022.95229

Case Report

A case of Erythroderma following Terbinafine therapy
[pdf]
[Abstract]

Rahma Yusuf Ali, Fatima Ali
DOI: 10.5742/MEWFM.2022.95230

Rare presentation of lower limb weakness, a case report
[pdf]
[Abstract]

Hamzeh Yousef khmour, Salma el Nour, Mansour Elmahdi
DOI: 10.5742/MEWFM.2022.95231

Original Clinical Research

Type 2 Diabetes Mellitus Control during COVID 19 Pandemic in Qatar 2020: A Retrospective Data Analysis
[pdf]
[Abstract]

Hamzeh Yousef Khmour, Yosaf Al-Rabeei, Nashwan Zainal Deen, Salma Elnour, Khaled Al-Karbi, Mostafa Hamdy Rashed, Muneera Al-Muhannadi, Mansour El-Mahdi, Hanan Al Shamari, Mustfa Abdelhamied abugesiesa, Ahmed Mahmoud Amer, Prem Chandra, Mohamed H. Mahmoud
DOI: 10.5742/MEWFM.2022.95233

Prevalence of Generalized Anxiety Disorder among Medical Residents in Hamad Medical Corporation in 2020
[pdf]
[Abstract]

Mohamed Hnish, Nashwan Zainal Deen, Salma Snoussi, Hind Mohamad, Mohamed Abdalla, Issameldin Abdelbagi
DOI: 10.5742/MEWFM.2022.95234

Contrast-Induced Nephropathy among adults after administration of intravenous material in the Emergency department at King Abdul-Aziz university hospital
[pdf]
[Abstract]

Abdullah Bakhsh, Samiyah Alsaedi, Afaf Alsaiari, Esraa Alzahrani, Latifah Kutbi, Bothainah Abed A Alsahafi, Ghoson ghonem alharbi, Mostafa Abdelsalam
DOI: 10.5742/MEWFM.2022.95235

Insulin Resistance Related to Metabolic Syndrome
[pdf]
[Abstract]

Hanan Taha AlShamery, Neelufur Sulaiman Sait
DOI: 10.5742/MEWFM.2022.95237

Middle East Quality Improvement Program
(MEQUIP QI&CPD)


Chief Editor -
Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE

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Publisher -
Lesley Pocock
medi+WORLD International
AUSTRALIA
Email
: lesleypocock@mediworld.com.au
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January 2022 - Volume 20, Issue 1

Insulin Resistance Related to Metabolic Syndrome

Received: November 2021; Accepted: December 2021; Published: January 1, 2022.
Citation: Hanan Taha AlShamery, Neelufur Sulaiman Sait. Insulin Resistance Related to Metabolic Syndrome. World Family Medicine. 2022; 20(1): 204-209 DOI: 10.5742/MEWFM.2022.95237

Abstract


Insulin resistance and metabolic syndrome are one of the major factors associated with higher risks of developing cardiovascular diseases and Type II Diabetes (T2D). Insulin resistance is believed to be one of the underlying causes of the development of T2D. There are numerous environmental and genetic factors influencing the development of these conditions, and while there have been many studies conducted on the topic, there are still many gaps in the scholarly literature on the topic. The interplay between genetic and environmental factors is quite complex, considering that there are many genes involved in the regulation of energy consumption as well as in the protective functions of an organism. Currently, the prevalence of insulin resistance among different populations ranges from 20% to 40%. Still, while the studies conducted before 2016 have found 88 loci associated with the development of T2D most of them are associated with secretion of insulin and function of -cell, and far fewer studies have identified loci associated with insulin resistance. This means that the vast majority of studies are either focused on the insulin response pathway or on the immune response to inflammatory processes caused by metabolic disorders.

It can be concluded that biological and genetic mechanisms underlying the development of insulin resistance in metabolic syndrome are complex. For now, it is known that insulin resistance in metabolic syndrome develops due to malfunctioning insulin response pathway, or malfunctioning chronic inflammation response system, and other problems associated with energy and fatty acid metabolism.

Considering that the rates of obesity and T2D indeveloping countries are alarming, it is highly important to develop effective evidence-based interventions targeting this problem.

Key words; Insulin resistance, genetic factors,Metabolic Syndrome, environmental factors, fatty acid metabolism.







 


 

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