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February 2022 -
Volume 20, Issue 2


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From the Editor

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Knowledge of complications of Type 2 diabetes mellitus among patients visiting the Diabetes Centers in the Western Region of KSA
[pdf]
[Abstract]
Fahad Almatrafi, Khalid Alshehri, Daifallah Almalki, Thamer Aldajani, Abdullah Alwthainani, Khalid Almatrafi, Faris Almatrafi, Renad Alqurashi, Ghala Almatrafi ,Lama Alkhaldi
DOI: 10.5742/MEWFM.2022.95240

Evaluation of outcome of distal humerus fracture fixation by two-locked plates
[pdf]
[Abstract]
Abdul Fatah Abbas Mansoor Haidarah
DOI: 10.5742/MEWFM.2022.95241

Familial Mediterranean fever may actually be a persistent inflammatory process on vascular endothelium all over the body
[pdf]
[Abstract]
Mehmet Rami Helvaci, Engin Altintas, Atilla Yalcin, Orhan Ekrem Muftuoglu,
Abdulrazak Abyad,Lesley Pocock
DOI: 10.5742/MEWFM.2022.95242

Assessment of Epidemic and Pandemic Events Preparedness in Ministry of Health Hospitals, Jazan, Saudi Arabia, 2021: A Cross-Sectional Study
[pdf]
[Abstract]
Ahmad Mosa Faqeeh, Abdullah Ibrahim Sabai. Mohammed Ahmed Jahlan, Ahmed Nasser Khayrat, Hussein Ali Azyabi, Abdullah Ibrahim Asiri, Mohammed Ali Azybi, Madi Mustafa Habkor
DOI: 10.5742/MEWFM.2022.95244

Strategies For Enhancing the Quality of Pediatric Emergency Care: Addressing Overcrowding and Patients' Length of Stay
[pdf]
[Abstract]
Amal Abdullah Alharbi, Maha Sanat Alreshidi
DOI: 10.5742/MEWFM.2022.95246

Population and Community Studies

Egg Allergy in Jeddah City - Saudi Arabia
[pdf]
[Abstract]
Moufag Mohammed Saeed Tayeb
DOI: 10.5742/MEWFM.2022.95247

Prevalence of childhood obesity, its associated risk factors and parental misperception of their child's actual weight among Saudi children in Yanbu city, Saudi Arabia 2021: A cross-sectional study
[pdf]
[Abstract]
Worood Abdulaziz Alodainy
DOI: 10.5742/MEWFM.2022.95248

Ocular Complications in diabetic children in Aseer region
[pdf]
[Abstract]
Ali Mohammed Al-Amri, Ibarhim Marie Shahrani, Ahmad Saad Al Zomia, Ahmed Falh Alayash, Muath Hussain Alhudaithi, Alhassan Alhussein Almonawar, Abdulaziz Mohammed Asiri, Meshari Hassan Asiri, Saeed Ali Alqarni
DOI: 10.5742/MEWFM.2022.95249

COVID-19 in the Region

Anxiety and coping strategies among COVID-19 patients in Medina, Saudi Arabia
[pdf]
[Abstract]
Shumukh Mohammed Alhejaili, Osama Madani Kiram, Duoaa Seddiq Abdoh, Sami Abdo Radman Al-Dubai
DOI: 10.5742/MEWFM.2022.95250

Case Reports

Unusual presentation of tinea corporis skin lesion - A Case Report
[pdf]
[Abstract]
Hanan K. Taha Alshammari, Neelufur Sulaiman Sait
DOI: 10.5742/MEWFM.2022.952502

Original Clinical Research

Contact Lens Use Patterns and Safety Determinants among Adolescents in Western Saudi Arabia
[pdf]
[Abstract]
Ahmed Basheikh
DOI: 10.5742/MEWFM.2022.952503

Middle East Quality Improvement Program
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Chief Editor -
Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE

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medi+WORLD International
AUSTRALIA
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February 2022 - Volume 20, Issue 2

Familial Mediterranean fever may actually be a persistent inflammatory process on vascular endothelium all over the body

(1) Specialist of Internal Medicine, MD
(2) Middle-East Academy for Medicine of Aging, MD
(3) Medi-WORLD International

Corresponding author:
Prof Dr Mehmet Rami Helvaci,
ALANYA, Antalya,
Turkey
Phone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received: December 2021; Accepted: January 2022; Published: February 1, 2022. Citation: Mehmet Rami Helvaci et al. Familial Mediterranean fever may actually be a persistent inflammatory process on vascular endothelium all over the body. World Family Medicine. 2022; 20(2): 27-32. DOI: 10.5742/MEWFM.2022.95242

Abstract

Background: We tried to understand whether or not there is a persistent inflammatory process in Familial Mediterranean Fever (FMF).

Methods: Consecutive patients with the FMF and controls were studied.

Results: The study included 39 patients with the FMF (18 females) and 39 controls. Mean age of the FMF patients was 27.5 ± 11.9 (11-58) years. Although the body weight and body mass index (BMI) were retarded in the FMF patients (64.6 versus 71.7 kg and 24.1 versus 25.7 kg/m2, respectively), the differences were nonsignificant probably due to the small sample size of the study (p>0.05). The mean body heights were similar in both groups (163.4 versus 166.8 cm, p>0.05). As negative acute phase reactants (APR), low density lipoproteins (LDL) (99.0 versus 114.3 mg/dL) and high density lipoproteins (HDL) (37.5 versus 44.5 mg/dL) were suppressed whereas triglycerides (TG) increased (110.2 versus 105.1 mg/dL) as positive APR, but the differences were nonsignificant probably due to the small sample size of the study, again (p>0.05). On the other hand, systolic blood pressures (BP) (115.0 versus 124.8 mmHg, p= 0.047) and diastolic BP (79.2 versus 88.9 mmHg, p= 0.001) were suppressed parallel to the suppressed body weight and BMI, significantly.

Conclusion: Although the FMF is described as intermittent attacks of painful inflammation, probably there is a persistent vascular endothelial inflammation all over the body. The suppressed body weight, BMI, LDL, HDL, and systolic and diastolic BP and the increased TG levels probably play roles of positive and negative APR in the systemic inflammatory process.

Key words: Familial Mediterranean fever, chronic endotelial damage, atherosclerosis, metabolic syndrome, acute phase reactants, triglycerides, blood pressure.

 







 


 

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