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December 2021 -
Volume 19, Issue 12


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From the Editor

Editorial
A. Abyad (Chief Editor)
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Original Contribution

Patients' Attendance to The Virtual Compared to The In-person Complimentary Outpatient Clinics at a Tertiary Care Hospital in Western Saudi Arabia: A Comparative Cross-sectional Study
[Abstract]
[pdf]
Mohammed Z. Altaf, Lina Z. Altaf, (2) Fayssal M Farahat, Abdulhakeem O. AlThaqafi
DOI: 10.5742/MEWFM.2021.94170

Knowledge around back pain and spinal disorders among Aseer patients: A cross sectional study
[Abstract]
[pdf]
Ibrahim Alburaidi, Saleh Saeed AlQahtani, Fahad mohammed saran, Zuhair Abshan Alshehri,
Rayan Dulaym Dashnan, Sultan Abdullah Al Mansour, Faisal al-Jahami, Shaker Alshehri,
Hani Fayez Ahmed Alasmari, Jamal Saad Saeed Alqahtani, Meshari Shar Alshehri
DOI: 10.5742/MEWFM.2021.94171

Environmental Triggers in Migraine patients in Riyadh: A Cross-Sectional Study
[Abstract]
[pdf]
Awad Al Harbi, Nada Hussain Alzahrani, Hanan Abdulkarim Alsuhibany, Manal Abdullah Al-Dosari, Reeman Salman Alsalman, Alanoud Abdulaziz Alkhalifah (2)
DOI: 10.5742/MEWFM.2021.94172

Job Satisfaction among Primary Health Care Workers in Buraidah, Qassim, Saudi Arabia
[Abstract]
[pdf]
Entisar AlJumail, Unaib Rabbani
DOI: 10.5742/MEWFM.2021.94173

Barriers to Compliance of Hypertensive Patients in Abha City, Saudi Arabia
[Abstract]
[pdf]
Alhussein Ali Almonawar, Ali Saeed Alasmary, Mohammed Mabkhoot Mogbel,
Hassan Mussa Almojamad
DOI: 10.5742/MEWFM.2021.94177

Disappearance of hepatitis C virus antibodies with hydroxyurea therapy in sickle cell diseases
[Abstract]
[pdf]
Mehmet Rami Helvaci, Engin Altintas, Atilla Yalcin, Orhan Ekrem Muftuoglu, Abdulrazak Abyad, Lesley Pocock
DOI: 10.5742/MEWFM.2021.94177

School Teachers' Knowledge and Attitude toward School Students with Epilepsy
[Abstract]
[pdf]
Rawan S. AlSuqair,Mohrah A. Alyabis,Marwa A. Algadi, Asmaa Attieh, Labani A. Juha,
Rama G. Alawa, Sarah G. Alghannam, Noora Z. Alsaadoon, Nervana A. Elsayed, Mona A. Alfadeel
DOI: 10.5742/MEWFM.2021.94183

Regional Covid

Increased Psychological Disorders among Pediatric Population during Covid
[Abstract]
[pdf]
Hamda Ahmed J H AlQaatri
DOI: 10.5742/MEWFM.2021.94174

Letter to the Editor
[pdf]
Mark Spigelman
DOI: 10.5742/MEWFM.2021.94192

Population and Community Studies

Patterns and determinants of Z score of Height for Age, Weight for Age and Weight for Height among Preschool children in Jeddah city, Saudi Arabia
[Abstract]
[pdf]
Fathi M. El-Gamal, Nuha Alsubhi, Shahd Badr, Nada Althaqafi, Fatima Al-Qadasi, Mariyam Hammed DOI: 10.5742/MEWFM.2021.94179

Effectiveness of Community Mental Health Service in Oman: A Pilot Study
[Abstract]
[pdf]
Saleha Al-Jadidi, Ahmed. S. Aboalatta, Iman Al-Rahbi, Maryiam Al-Harrasi,
Hamood AlRauzaiqi, Musa Abu Sabeih, Thuraiya AlGammari, Ahmed Al-Shammakhi
DOI: 10.5742/MEWFM.2021.94180

Proton Pump Inhibitors Awareness among Physicians and Pharmacists in Primary Healthcare Centres in Abha, Saudi Arabia
[Abstract]
[pdf]
Ibrahim Hasan Alasmari, Majed Mohammed AL Saleh, Majed Ali Alahmari, Sawsan Mohammad Asiri, Aljawhara Yahya Asiri
DOI: 10.5742/MEWFM.2021.94184

Knowledge, Attitude and Practice of Non-Psychiatric Physicians about Addiction
[Abstract]
[pdf]
Saeed M. Al-Ahmari, Ali A. Almusa, Ali A. Alshomrani, Waleed S.H. Al Ahmary,
Zahra S.A. Assiry, Suad M.S. Alqahtany, Ahmed Yahya Asiri, Turki Hassan Alqahtani,
Nasser Saeed Alassiri, Ossama A. Mostafa
DOI: 10.5742/MEWFM.2021.94185

Risk Factors for Diabetic Ketoacidosis among Type 1 Diabetic Children Registered at "Heraa Diabetes Center" in Makkah Al-Mokarramah City, Saudi Arabia
[Abstract]
[pdf]
Waleed K. Ballaji, Hassan M. Hadadi
DOI: 10.5742/MEWFM.2021.94186

Physicians’ Perspectives of Barriers to Insulin Initiation for Adults with Type 2 Diabetes Mellitus in Primary Health Care Centers (PHCCs), Tabouk Province - Kingdom of Saudi Arabia (KSA)
[Abstract]
[pdf]
Sameh F. Ahmed, Ghurmallah A. Alghamdi, Amerah A. Albalawi, Majed S. Alqahtani, Ibrahim M. Ghonim, Hoda M. Elhady, Shimaa A. Abdelhamid, Abderahman A. Eldesouky
DOI: 10.5742/MEWFM.2021.94189

Review

Role of SGLT2 Inhibitors and GLP-1 Analogs in Cardiovascular Risk Reduction in Type 2 Diabetes
[Abstract]
[pdf]
Mostafa Hamdy Rashed, Tonbra Deborah Dauyoumor, Sarah Corney,
Kimberly Konono, Nadia Joubert, Marwa Mohamed, Michon Sukhoo-Pertab,
Mobowa Makhomisane, Irene Njeri, Julius Mwita, Mariam Sefen,
Khadija Mohamed, Nicolette Whiley
DOI: 10.5742/MEWFM.2021.94188

Diagnostic approach to eosinophilia in children
[Abstract]
[pdf]
Raghba Shasho
DOI: 10.5742/MEWFM.2021.94190

Original Clinical Research

Machine Learning in Otorhinolaryngology, Head and Neck Surgery and its applications in diagnosis and management: Undergraduates Perception toward New Era
[Abstract]
[pdf]
Saleh Abdulmoneim Alomary, Belal Abdullah Alorainy , Naif Saleh Albargan, Fahad Z. Alotaibi
Feras Alkholaiwi
DOI: 10.5742/MEWFM.2021.94191


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Middle East Quality Improvement Program
(MEQUIP QI&CPD)

Chief Editor -
Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE
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Editorial Office -
Abyad Medical Center & Middle East Longevity Institute
Azmi Street, Abdo Center,
PO BOX 618
Tripoli, Lebanon
Phone: (961) 6-443684
Fax:     (961) 6-443685
Email: aabyad@cyberia.net.lb
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Publisher -
Lesley Pocock
medi+WORLD International
AUSTRALIA
Email: lesleypocock@mediworld.com.au
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Editorial Enquiries -
abyad@cyberia.net.lb
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Advertising Enquiries -
lesleypocock@mediworld.com.au
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December 2021 - Volume 11, Issue 12

Disappearance of hepatitis C virus antibodies with hydroxyurea therapy in sickle cell diseases


Mehmet Rami Helvaci (1)
Engin Altintas (1)
Atilla Yalcin (1)
Orhan Ekrem Muftuoglu (1)
Abdulrazak Abyad (2)
Lesley Pocock (3)

(1) Specialist of Internal Medicine, MD
(2) Middle-East Academy for Medicine of Aging, MD
(3) medi+WORLD International

Corresponding author:
Prof Dr Mehmet Rami Helvaci,
07400, ALANYA, Turkey
Phone: 00-90-506-4708759
Email: mramihelvaci@hotmail.com

Received: October 2021; Accepted: November 2021; Published: December 1, 2021.
Citation: Mehmet Rami Helvaci et al. Disappearance of hepatitis C virus antibodies with hydroxyurea therapy in sickle cell diseases. World Family Medicine. 2021; 19(12): 43-49. DOI: 10.5742/MEWFM.2021.94177

Abstract



Background: We tried to understand whether or not there is a disappearance of hepatitis C virus antibodies (anti-HCV) with hydroxyurea therapy in patients with sickle cell diseases (SCD).

Methods: All patients with the SCD were included, and hydroxyurea therapy was initiated for all of them.

Results: The study included 337 patients (169 females and 168 males). Hydroxyurea therapy was well-tolerated with a high majority of cases (80.1%). Mean number of painful crises per year was decreased with the therapy (10.3 versus 1.7 crises per year, p<0.000). Mean severity of painful crises was decreased, too (7.8 versus 2.2, p<0.001). Although the body weight, mean hematocrit (Hct) value, and mean corpuscular volume (MCV) increased, white blood cells (WBC) and platelets (PLT) counts and the total and direct bilirubin, and lactate dehydrogenase (LDH) levels of plasma decreased with the therapy (p<0.000 for all). Similarly, 23 patients (6.8%) with anti-HCV positivity before the therapy decreased to 16 patients (4.7%, p>0.05) with hydroxyurea.

Conclusion: SCD are chronic inflammatory disorders with high morbidity and mortality rates, and hydroxyurea is a well-tolerated and highly effective regimen for them. While hydroxyurea therapy decreases both frequency and severity of painful crises, WBC and PLT counts, total and direct bilirubin, and LDH levels, it increases body weight, Hct value, and MCV. Although hydroxyurea therapy also decreased the anti-HCV positivity, the difference was nonsignificant probably due to the small sample size of the present study.

Key words: Sickle cell diseases, chronic endothelial damage, atherosclerosis,
metabolic syndrome, hepatitis C virus antibodies, hydroxyurea







 


 
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