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Abdulrazak Abyad MD, MPH, MBA, AGSF, AFCHSE

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EDITORIAL September 2025

Confronting Health Challenges Across Disciplines - From Chronic Disease to Social Determinants


The manuscripts in this collection traverse a wide range of pressing health issues, yet they share a unifying theme: the interplay of medical science, clinical practice, and societal factors in shaping human well-being. From chronic disease management and rare diagnostic challenges to social determinants of health and maternal awareness, the papers collectively demonstrate that effective healthcare requires a holistic approach that integrates biological, psychological, and cultural dimensions.

Obesity and hypertension, among the most prevalent risk factors for global morbidity, remain at the forefront. Beyond their metabolic consequences, obesity carries the added burden of stigma, with patients often facing discrimination in healthcare and society at large, leading to poorer outcomes and delays in care. Similarly, gaps in hypertension management persist, as seen in audits showing underuse of guideline-recommended assessments; however, structured electronic tools demonstrate that small systemic changes can significantly improve compliance and patient outcomes. Together, these works remind us that treating chronic disease requires not only effective therapeutics but also attention to the environments-clinical and social-in which patients live.

Clinical vigilance is emphasized in case-based insights, such as the report of celiac disease presenting solely as liver enzyme elevation, underscoring the need to consider seronegative presentations when standard serology is negative. At the other end of the spectrum, innovation in therapeutics raises both hope and caution. Tirzepatide, hailed as a breakthrough in weight and diabetes management, demonstrates unparalleled efficacy in weight loss and glycemic control, yet long-term cancer and pancreatitis risks remain inadequately understood. Similarly, reflections on older agents such as acarbose in preventing stroke place established therapies in new preventive contexts, highlighting the evolving nature of clinical application.
The burden of aging is powerfully represented through dementia and bone health. A comprehensive overview of dementia reminds us that cognitive decline is not inevitable with aging, and that subtypes such as Alzheimer's disease, vascular dementia, and Lewy body dementia pose unique diagnostic and management challenges. The rising prevalence has profound implications for patients, families, and healthcare systems worldwide. Complementary to this, research into vitamin D deficiency and fracture patterns in Saudi Arabia underscores how lifestyle, cultural practices, and limited sun exposure contribute to fragility fractures, especially among younger populations and women. Together, these findings illuminate the urgent need for preventive strategies in aging societies.

Maternal and child health emerges as another crucial theme. The study of primary healthcare physicians in Saudi Arabia revealed strong theoretical knowledge of gestational diabetes but limited practical engagement, underscoring the gap between training and real-world implementation. The paper on maternal awareness of child trauma adds another dimension, showing that despite the high burden of injuries-falls, burns, and accidents-maternal awareness of first aid and prevention remains inadequate. This gap underscores the need for education programs to empower families, as child trauma not only carries immediate risks but also long-term consequences for development, chronic disease vulnerability, and mental health.

Health is also shaped by culture, economics, and media. The reflection on cosmetic surgery highlights the dangers of unregulated interventions such as the Brazilian Butt Lift, fueled by social media and unrealistic body ideals. Equally, food insecurity and consumer responses to rising egg prices in the U.S. illustrate how economic shocks reshape dietary patterns, disproportionately affecting low-income and minority communities and raising broader questions of equity and resilience in food systems.

Taken together, these diverse contributions reveal medicine not as a series of isolated disciplines but as a deeply interconnected ecosystem. Chronic disease management cannot be divorced from stigma and culture; maternal and child health requires both clinical expertise and community education; therapeutics must balance innovation with vigilance for long-term safety; and societal trends-from social media to food inflation-bear directly on health outcomes.

The collective message of this issue is clear: progress in health demands an integrated approach that bridges biomedical research, clinical vigilance, social awareness, and policy innovation. By weaving these strands together, we can move toward a more responsive, equitable, and effective healthcare landscape-one that honors the complexity of human health while striving for tangible improvements in quality of life.

Warm regards,

Dr. Abdulrazak Abyad
Editor-in-Chief
Middle East Journal of Family Medicine

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