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WFM / MEJFM September Issue 6, 2025

Atypical Presentation of Celiac Disease in asymptomatic adult with no significant medical history : A rare diagnostic challenge

Adnan Ali 1, Sirfraz Hussain 1, Alaa Daban 2, Azza Awad Saad 3

1 - Consultant Family Medicine, PHCC, Qatar2 - Specialist Family Medicine, PHCC, Qatar
3 - Senior Consultant Family Medicine and Manager, PHCC Qatar

Correspondence:
Consultant Family Medicine
Operations - HC Gharrafat Al Rayyan
P.O. Box 26555 | Doha | Qatar
Web: www.phcc.gov.qa
Email: adali@phcc.gov.qa

Received: August 2025. Accepted: August 2025; Published: September/October, 2025.Citation: Adnan Ali et al. Atypical Presentation of Celiac Disease in asymptomatic adult with no significant medical history : A rare diagnostic challenge. World Family Medicine September 2025; 23(6): 84 - 86. DOI: 10.5742/MEWFM.2025.805257897


Abstract


Background: Celiac disease mainly presents with gastrointestinal symptoms, but atypical presentations, including liver dysfunction, are increasingly recognized.

Case Presentation: We report the case of a 49-year-old asymptomatic healthy gentleman, having mildly elevated cholesterol managed through healthy lifestyle. He had no history of alcohol or drugs intake and a negative family history of Celiac or liver disease. Patient was incidentally found to have markedly elevated liver transaminases on routine blood tests. Subsequent detailed workup for elevated liver transaminases including Celiac serology was normal.

Conclusion: Celiac disease must be considered in the differential diagnosis of the patients with unexplained liver enzyme abnormalities without gastrointestinal symptoms and negative serological tests.

Keywords: Celiac disease (CD), Seronegative Celiac disease (SNCD), Liver enzymes, Gluten-free diet





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