|
|
|
|
|
Chief
Editor -
Abdulrazak
Abyad
MD, MPH, MBA, AGSF, AFCHSE
.........................................................
Editorial
Office -
Abyad Medical Center & Middle East Longevity
Institute
Azmi Street, Abdo Center,
PO BOX 618
Tripoli, Lebanon
Phone: (961)-3-201901
Email:
amcmeli@gmail.com
aabyad@cyberia.net.lb
.........................................................
Publisher
-
Lesley
Pocock
medi+WORLD International
AUSTRALIA
Email:
lesleypocock@mediworld.com.au
publishermwi@gmail.com
.........................................................
Editorial
Enquiries -
abyad@cyberia.net.lb
.........................................................
Advertising
Enquiries -
lesleypocock@mediworld.com.au
.........................................................
While all
efforts have been made to ensure the accuracy
of the information in this journal, opinions
expressed are those of the authors and do not
necessarily reflect the views of The Publishers,
Editor or the Editorial Board. The publishers,
Editor and Editorial Board cannot be held responsible
for errors or any consequences arising from
the use of information contained in this journal;
or the views and opinions expressed. Publication
of any advertisements does not constitute any
endorsement by the Publishers and Editors of
the product advertised.
The contents
of this journal are copyright. Apart from any
fair dealing for purposes of private study,
research, criticism or review, as permitted
under the Australian Copyright Act, no part
of this program may be reproduced without the
permission of the publisher.
|
|
|
| WFM
/ MEJFM September 2023 |
|
|
Vitamin
B-12 deficiency in type 2 diabetes
patients on metformin therapy –
A narrative review
Amir Tauqir
Chaudhary 1, Shiraz Ali A
2
(1)Specialist Family Medicine
Norway, Tutor Family Medicine Norway,
Consultant Family Medicine PHCC
Qatar
(2) A&E GP Clinical Lead BTHFT,
Bradford Royal Infirmary, Duckworth
Lane, BD9 6RJ, England, Consultant
Family Medicine PHCC Qatar
Corresponding author:
Dr. Amir Tauqir Chaudhary, MBBS
(Pak),
MD (Equivalence exam with UiO Norway),
Specialist Family Medicine Norway,
Tutor Family Medicine Norway,
Consultant Family Medicine PHCC
Qatar
Mobile: 00974 51094681
Email: amirtauqeernw@hotmail.com
Received: July 2023. Accepted:
August 2023; Published: September
1, 2023.Citation: Amir Tauqir Chaudhary,
Shiraz Ali. Vitamin B-12 deficiency
in type 2 diabetes patients on metformin
therapy – A narrative review.
World Family Medicine. August 2023;
21(8): 44-54. DOI: 10.5742/MEWFM.2023.95256179
|
Abstract
Due
to its increased incidence
and related complications,
T2DM (Type 2 diabetes mellitus)
is becoming an issue of public
health concern. This narrative
review elucidates association
between metformin therapy
in T2DM and cobalamin (Vit.
B12) deficiency. According
to various studies, diabetic
patients receiving metformin
medication had a higher risk
of Vit. B12 (vitamin B12)
deficiency than those T2DM
patients not receiving metformin
therapy, ranging from 14%
to 22.4% in those taking metformin
and from 6% to 10% in those
not taking metformin. Odds
ratios for Vit. B12 deficiency
associated with using metformin
ranged from 2.2 to 2.7, indicating
a moderate to high risk. The
management of Vit. B12 deficiency
in T2DM involves a combination
of accurate diagnosis, appropriate
supplementation strategies,
patient education, and interdisciplinarycollaboration.
Consensus and guidelines recommend
routine monitoring of serum
vitamin B12 levels, high-dose
oral supplementation, intramuscular
injections for severe deficiency,
and consideration of alternative
routes of administration,
along with lifestyle modifications.
Keywords:
Diabetes mellitus type 2,
Metformin therapy, Vitamin
B12, Management, and treatment
|
|
|
|
|
.................................................................................................................
|
|
